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KMID : 0043320130360020208
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Archives of Pharmacal Research
2013 Volume.36 No. 2 p.208 ~ p.222
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Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 Diabetes
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Lee Jong-Soon
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Abstract
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It has been increasingly accepted that chronic subacute inflammation plays an important role in the development of insulin resistance and type 2 Diabetes in animals and humans. Particularly supporting this is that suppression of systemic inflammation in type 2 Diabetes improves glycemic control; this also points to a new potential therapeutic target for the treatment of type 2 Diabetes. Recent studies strongly suggest that obesity-induced inflammation is mainly mediated by tissue resident immune cells, with particular attention being focused on adipose tissue macrophages (ATMs). This review delineates the current progress made in understanding obesity-induced inflammation and the roles ATMs play in this process.
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KEYWORD
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Adipose tissue macrophage (ATM), Insulin resistance, Obesity, Inflammation
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